DNA, the long polymer curled up inside our cells, is often described as the instructions for life. But those instructions are stored in DNA’s chemical code, and reading that code requires the ...

Proceedings of the National Academy of Sciences of the United States of America, Vol. 113, No. 13 (March 29, 2016), pp. E1816-E1825 (11 pages) Transcription is an intrinsically dynamic process and ...

A team used the 200-petaflop IBM AC922 Summit system, the world's smartest and most powerful supercomputer, to develop an integrative model of the transcription preinitiation complex (PIC), a complex ...

An error in a gene, a mutation, can cause a disease, but the relationship between the genome of an organism and its physical characteristics, and exactly how genetic ...

This is a preview. Log in through your library . Abstract After synthesis of a short nascent RNA, RNA polymerase II (pol II) dissociates general transcription factors (GTFs; TFIIA, TFIIB, TBP, TFIIE, ...

The goal of this line of research is to investigate the assembly mechanism, dynamics, and heterogeneity of human transcription factor/DNA complexes, and how these parameters contribute to ...

Findings could help pave the way for cancer therapies that target TAF12, potentially stopping transcription in cancer cells and helping decrease the growth of cancerous tumors. Scientists from the ...

Genetic factors can be responsible for a number of diseases, from degenerative neurological disorders to some cancers. Gene mutations can interfere with how the body expresses genes and cause disease.

Environmental conditions, lifestyle choices, chemical exposure, and foodborne and airborne pathogens are among the external factors that can cause disease. In contrast, internal genetic factors can be ...