The present report deals with the in vitro anti-microbial activity of novobiocin and its efficacy in the treatment of a variety of surgical infections due to staphylococci and other gram-positive ...

STAPHYLOCOCCAL infections acquired in hospitals continue to present serious problems, particularly since strains of nosocomial origin are frequently resistant to virtually all antibiotics. During the ...

Through adaptive laboratory evolution, key resistance mutations (in gyrB, potB, and fpgS) in S. aureus were identified after repeated exposure to novobiocin. Further metabolomic analysis revealed the ...