As the importance and prevalence of oligonucleotide therapeutics continue to grow, so does the need for robust characterization methodologies throughout drug development and production. Given the ...

Fluorinated compounds are increasingly used in medicinal, agricultural, and material science applications. NMR probes and procedures were historically employed to get hydrogen and carbon spectra.

Intrinsically disordered proteins (IDP) are proteins that lack tertiary structure. They are now being recognized as biologically crucial in both healthy systems and the pathophysiology of various ...

Fragment-based drug discovery (FBDD) has emerged as a transformative approach in medicinal chemistry by focusing on the identification of small chemical fragments that bind to biologically relevant ...

NMR spectroscopy is among the most powerful analytical techniques for the elucidation of chemical structure. It has the capability of providing detailed information about structure and dynamics of ...

In this editorial, Enrico Ravera gives an overview of the use of paramagnetic metals in NMR and explains how this can provide crucial information about the structure and dynamics of proteins, nucleic ...

RNA plays a crucial role in every phase of the cell life cycle, with misregulation frequently resulting in disease. Recent breakthroughs in understanding RNA biochemistry, structure, and dynamics have ...

Researchers have achieved a breakthrough in zero-field nuclear magnetic resonance spectroscopy, paving the way towards benchmarking quantum chemistry calculations. What is the structure of a ...

Nuclear magnetic resonance (NMR) spectroscopy could be about to go mobile, thanks to a team of researchers in the US that has shrunk the electronic components needed for the spectroscopic technique ...

Structural biology is a field of science that uses a variety of techniques to determine the 3D structures of biomolecules such as proteins, nucleic acids and their complexes. These techniques allow ...