Never-before-seen 3D reconstructions of human liver tissue have been created at a cellular level. The details obtained by a team of UW Medicine and University of Washington engineers and physicians ...

Using human liver samples and a mouse model of cirrhosis, researchers identified epigenetic overactivation of the inflammatory PAF–PAF-R pathway in hepatic macrophages as a key driver of liver damage.

Your liver performs over 500 essential functions every single day, yet most people remain completely unaware when this vital organ begins failing until damage reaches catastrophic levels that may be ...

Scientists have published a ground-breaking study of the structure and function of a central protein in the liver: NTCP, a cellular-entry pathway for bile salts, but also for certain hepatitis viruses ...

The liver produces bile, which the intestine uses for digestion. For the transport of bile, the liver relies on a network of microscopic tubings, known as bile canaliculi, formed by liver cells called ...

Over time, this damages liver cells, triggers inflammation and contributes to fibrosis, which is the build-up of scar tissue. If scarring becomes extensive, it can progress to cirrhosis, a stage where ...

Though an essential gateway to the liver, NTCP had not been well described until now. Na+-taurocholate co-transporting polypeptide (NTCP) is a protein located exclusively in the membrane of liver ...