Proceedings of the National Academy of Sciences of the United States of America, Vol. 113, No. 21 (May 24, 2016), pp. 5916-5921 (6 pages) DNA replication occurs semidiscontinuously due to the ...

DNA replication is a basic function of living organisms, allowing cells to divide and multiply, all while maintaining the genetic code and proper function of the original cell. The process, or ...

Half a century ago, scientists Jim Watson and Alexey Olovnikov independently realized that there was a problem with how our DNA gets copied. A quirk of linear DNA replication dictated that telomeres ...

Figure 1: The topological problem caused by coupled leading- and lagging-strand polymerases. Figure 2: Signal release does not require primase and correlates with increasing Okazaki fragment length.

For the first time ever, scientists have captured a single DNA molecule replicating on video — and it’s changing the way we think about the entire process. One of the most surprising findings is how ...

The process begins by unzipping DNA's ladder-like structure, resulting in two strands called the leading and lagging strands. A molecular construction crew then assembles the missing halves of the ...

Humans and baker’s yeast have more in common than meets the eye, including an important mechanism that helps ensure DNA is copied correctly, reports a pair of studies published in the journals Science ...