Linerixibat targets pruritus pathobiology in PBC by blocking ileal bile acid reuptake, aiming to lower circulating pruritogenic bile acid–related mediators. GLISTEN demonstrated greater 24-week WI-NRS ...
The FDA approved linerixibat (Lynavoy) as the first drug indicated for cholestatic pruritus stemming from primary biliary cholangitis (PBC), drugmaker GSK announced on Thursday.
The oral ileal bile acid transporter inhibitor significantly and rapidly reduced cholestatic pruritus in patients with PBC in the phase 3 GLISTEN trial.
Cholestatic liver diseases (CLDs) are a group of disorders characterized by the impairment of bile formation, secretion, or excretion. This impairment leads to bile acid accumulation in the liver, ...
Bile acids are essential signaling molecules derived from cholesterol metabolism in the liver and are crucial for the digestion and absorption of fats. These molecules undergo further modification in ...
Please provide your email address to receive an email when new articles are posted on . Patients with PBC and cirrhosis treated with seladelpar exhibited greater reductions in ALP, GGT and ALT at 12 ...
Please provide your email address to receive an email when new articles are posted on . In this video, Nancy S. Reau, MD, FAASLD, AGAF, discusses 36-month results from the ongoing phase 3 ASSURE ...
Bile acids are essential signaling molecules derived from cholesterol metabolism in the liver and are crucial for the digestion and absorption of fats. These molecules undergo further modification in ...
To highlight the importance of actively looking for concomitant cCMV as a routine evaluation of patients presenting with cholestasis and receiving a diagnosis of an inherited liver disease, ...
TORONTO, February 05, 2026--(BUSINESS WIRE)--Mirum Pharmaceuticals, Inc. (Nasdaq: MIRM), a leading rare disease company, today announced that Health Canada has authorized the tablet formulation of ...
Liver tests should be obtained in all patients with suspected DILI. Calculating the ratio of the alanine aminotransferase (ALT) value/ALT upper limit of normal (ULN) divided by the alkaline ...
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